Total and Central Adiposity Are Associated With Age at Gonadarche and Incidence of Precocious Gonadarche in Boys

Abstract Context A close link between body mass index (BMI) and female pubertal onset is well established. However, observations in boys remain inconclusive. Objective We aim to determine whether BMI as total central adiposity prepubertal Chilean associated with timing. Methods performed a longitudinal study which 494 from the Growth Obesity Cohort Study were followed starting birth throughout puberty, including 5 visits. The main outcome measures included anthropometric data semi-annual clinical staging. association BMI, obesity (BMI standard deviation score [SDS] ≥ 2) (waist circumference 90th centile) precocious puberty age at gonadarche was analyzed using survival- logistic regression models. Results prevalence of obesity, increased childhood. Among population, 45 entered before 9 years (9.1%). 4 7 childhood mean SDS significantly gonadarche. Mean testicular enlargement (≥4 mL), 11.0 (95% CI, 10.9-11.1) inversely SDS, waist circumference, percentage fat almost all Age normal weight, overweight, obese 11.2 (11.0-11.3), 10.9 (10.6-11.1) 10.7 (10.4-11.1) years, respectively. Conclusion Our observation supports timing boys, Early intervention controlling epidemic could be useful decreasing detrimental impact on later health.